I periodically prune back my tomatoes. Since I grow them so close together, they need trimming to keep the air circulating and to put the most plant energy into making fruit, instead of leaves. Frequently I have people ask me if I'm afraid I'm going to kill them... Well, I've been doing this for years and always get tons of tomatoes.
During the trimming I found one Roma plant that hasn't set any tomatoes yet. I'm not sure why, since 4 other Romas (from a different supplier) have set quite a bit of fruit. I'll keep watching!